Risperidone-Induced Hiccups in an Adolescent

Hiccups are involuntary spasmodic contractions of the diaphragm and inspiratory intercostal muscles followed by sudden closure of glottis which leads to halting the start of an inspiration. There are many factors which may cause hiccups. Although the exact pathophysiological processes involved have not yet been established, the neurotransmitters dopamine, serotonin and gamma amino butyric acid (GABA) have been documented to play a significant role in the generation of hiccups. Here, we present a case of risperidone-induced hiccups in a 14-year old adolescent to discuss the probable causes, the etiology and the clinical outcomes of this side effect.